Drug Information

Drug General Information
Drug ID
DX3LT8
Drug Name
4-{(R)-Carboxy-[5-phenylthiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic Acid iso-propyl Ester
Synonyms
CHEMBL468738
Indication Discovery agent Investigative [1587926]
Formula
C21H26N2O6S2
Canonical SMILES
CC(C)OC(=O)N1CCC(CC1)[C@@H](NS(=O)(=O)c2ccc(s2)c3ccccc3)C(=O)O
InChI
InChI=1S/C21H26N2O6S2/c1-14(2)29-21(26)23-12-10-16(11-13-23)19(20(24)25)22-31(27,28)18-9-8-17(30-18)15-6-4-3-5-7-15/h3-9,14,16,19,22H,10-13H2,1-2H3,(H,24,25)/t19-/m1/s1
InChIKey
UPNGQGNTHSPTJW-LJQANCHMSA-N
Target and Pathway
Target(s) Collagenase 3 Target Info [1587926]
Interstitial collagenase Target Info [1587926]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingendothelinpathway:Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
Bladder Cancer
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.