Drug Information

Drug General Information
Drug ID
DX3PX0
Drug Name
2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)-N-phenylthiazole-5-carboxamide
Synonyms
CHEMBL482774
Indication Discovery agent Investigative [1587926]
Formula
C26H28N6O4S
Canonical SMILES
COc1cc2c(Nc3ncc(s3)C(=O)Nc4ccccc4)ncnc2cc1OCCCN5CCOCC5
InChI
InChI=1S/C26H28N6O4S/c1-34-21-14-19-20(15-22(21)36-11-5-8-32-9-12-35-13-10-32)28-17-29-24(19)31-26-27-16-23(37-26)25(33)30-18-6-3-2-4-7-18/h2-4,6-7,14-17H,5,8-13H2,1H3,(H,30,33)(H,27,28,29,31)
InChIKey
ROGHHIGHHTZCFT-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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