Drug General Information
Drug ID
DX3RBZ
Drug Name
2-methyl-3-(5-methyl-3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
Synonyms
CHEMBL218431
Indication Discovery agent Investigative [1587926]
Formula
C31H31F3N6O2
Canonical SMILES
CNc1nccc(n1)c2cc(C)cnc2Oc3cccc(C(=O)Nc4cc(ccc4N5CCCCC5)C(F)(F)F)c3C
InChI
InChI=1S/C31H31F3N6O2/c1-19-16-23(24-12-13-36-30(35-3)39-24)29(37-18-19)42-27-9-7-8-22(20(27)2)28(41)38-25-17-21(31(32,33)34)10-11-26(25)40-14-5-4-6-15-40/h7-13,16-18H,4-6,14-15H2,1-3H3,(H,38,41)(H,35,36,39)
InChIKey
WDEPCTJBPQDCEB-UHFFFAOYSA-N
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 2 Target Info [1587926]
Angiopoietin 1 receptor Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Rheumatoid arthritis
NetPath Pathway IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathwayP00005:Angiogenesis
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP363:Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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