TTD | Drug: DX3RVU

Drug General Information
Drug ID	DX3RVU
Drug Name	N1-[3-(5-[6-(4-Hydroxypiperidino)-2-methyl-4-pyrimidinyl]amino-1H-3-pyrazolyl)phenyl]-1-benzenesulfonamide
Synonyms	CHEMBL1807785
Indication	Discovery agent		Investigative	[1587926]
Formula	C25H27N7O3S
Canonical SMILES	Cc1nc(Nc2cc(n[nH]2)c3cccc(NS(=O)(=O)c4ccccc4)c3)cc(n1)N5CCC(O)CC5
InChI	InChI=1S/C25H27N7O3S/c1-17-26-23(16-25(27-17)32-12-10-20(33)11-13-32)28-24-15-22(29-30-24)18-6-5-7-19(14-18)31-36(34,35)21-8-3-2-4-9-21/h2-9,14-16,20,31,33H,10-13H2,1H3,(H2,26,27,28,29,30)
InChIKey	KFRUZRAQPBNGME-UHFFFAOYSA-N
Target and Pathway
Target(s)	Aurora kinase A	Target Info		[1587926]
Target(s)	FL cytokine receptor	Target Info		[1587926]
KEGG Pathway	Oocyte meiosishsa04060:Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Pathways in cancer
	Transcriptional misregulation in cancer
	Acute myeloid leukemia
	Central carbon metabolism in cancer
Pathway Interaction Database	Aurora B signaling
	Signaling by Aurora kinases
	Integrin-linked kinase signaling
	PLK1 signaling events
	Aurora A signaling
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome	Regulation of PLK1 Activity at G2/M Transition
WikiPathways	EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926	URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926	URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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Drug Information