Drug Information

Drug General Information
Drug ID
DX4LFW
Drug Name
6-methoxy-N-(5-methyl-1,3-thiazol-2-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Synonyms
CHEMBL201654
Indication Discovery agent Investigative [1587926]
Formula
C20H25N5O3S
Canonical SMILES
COc1cc2c(Nc3ncc(C)s3)ncnc2cc1OCCCN4CCOCC4
InChI
InChI=1S/C20H25N5O3S/c1-14-12-21-20(29-14)24-19-15-10-17(26-2)18(11-16(15)22-13-23-19)28-7-3-4-25-5-8-27-9-6-25/h10-13H,3-9H2,1-2H3,(H,21,22,23,24)
InChIKey
ANIODNBRYFSVJO-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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