Drug General Information
Drug ID
DX4ZHA
Drug Name
3-Imidazo[1,2-a]pyridin-3-yl-4-[9-methyl-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl]-pyrrole-2,5-dione
Synonyms
CHEMBL186290
Indication Discovery agent Investigative [1587926]
Formula
C29H28N6O3
Canonical SMILES
Cc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c5cnc6ccccn56)c(c1)c23)C(=O)N7CCCCC7
InChI
InChI=1S/C29H28N6O3/c1-18-13-19-16-34(29(38)32-8-4-2-5-9-32)12-11-33-17-21(20(14-18)26(19)33)24-25(28(37)31-27(24)36)22-15-30-23-7-3-6-10-35(22)23/h3,6-7,10,13-15,17H,2,4-5,8-9,11-12,16H2,1H3,(H,31,36,37)
InChIKey
LQESNGDPCQOCKO-UHFFFAOYSA-N
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info [1587926]
Transforming growth factor receptor b Target Info [1587926]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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