Drug General Information
Drug ID
DX5GH3
Drug Name
N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-3-methoxy-benzamide
Synonyms
CHEMBL480634
Indication Discovery agent Investigative [1587926]
Formula
C24H35N3O7S
Canonical SMILES
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC2(C)CCCC2)NC(=O)c3ccc(NS(=O)(=O)C)c(OC)c3
InChI
InChI=1S/C24H35N3O7S/c1-5-19-21(18(28)14-34-19)26-23(30)17(13-24(2)10-6-7-11-24)25-22(29)15-8-9-16(20(12-15)33-3)27-35(4,31)32/h8-9,12,17,19,21,27H,5-7,10-11,13-14H2,1-4H3,(H,25,29)(H,26,30)/t17-,19-,21+/m0/s1
InChIKey
GVXZIDMCXUICPR-HFSMHLIXSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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