Drug General Information
Drug ID
DX5HPM
Drug Name
(S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
Synonyms
CHEMBL1289440
Indication Discovery agent Investigative [1587926]
Formula
C30H31F4N3O3S
Canonical SMILES
CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)c2ccc(cc2)S(=O)(=O)C)C(F)(F)F)C(=O)N[C@@H](Cc3ccccc3)C#N
InChI
InChI=1S/C30H31F4N3O3S/c1-29(2,31)18-26(28(38)36-24(19-35)17-20-7-5-4-6-8-20)37-27(30(32,33)34)23-11-9-21(10-12-23)22-13-15-25(16-14-22)41(3,39)40/h4-16,24,26-27,37H,17-18H2,1-3H3,(H,36,38)/t24-,26-,27-/m0/s1
InChIKey
IYGWXNGZSDQPFR-URORMMCBSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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