Drug General Information
Drug ID
DX5KM7
Drug Name
N1-ethyl-N4-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-1,4-dicarboxamide
Synonyms
CHEMBL497012
Indication Discovery agent Investigative [1587926]
Formula
C26H30N4O6S
Canonical SMILES
CCNC(=O)N1CCC(CC1)(C(=O)NO)S(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2
InChI
InChI=1S/C26H30N4O6S/c1-3-27-25(32)30-14-12-26(13-15-30,24(31)29-33)37(34,35)21-10-8-20(9-11-21)36-17-19-16-18(2)28-23-7-5-4-6-22(19)23/h4-11,16,33H,3,12-15,17H2,1-2H3,(H,27,32)(H,29,31)
InChIKey
XQTUJUSPSCMEOC-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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