Drug General Information
Drug ID
DX5OOH
Drug Name
[(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid (1S,3S,5R)-3,5-dimethyl-cyclohexyl ester
Synonyms
CHEMBL371749
Indication Discovery agent Investigative [1587926]
Formula
C24H36N2O4
Canonical SMILES
CCCC[C@H](NC(=O)OC1C[C@H](C)C[C@H](C)C1)C(=O)C(=O)N[C@H](C)c2ccccc2
InChI
InChI=1S/C24H36N2O4/c1-5-6-12-21(26-24(29)30-20-14-16(2)13-17(3)15-20)22(27)23(28)25-18(4)19-10-8-7-9-11-19/h7-11,16-18,20-21H,5-6,12-15H2,1-4H3,(H,25,28)(H,26,29)/t16-,17+,18-,20-,21+/m1/s1
InChIKey
ZXHXXGCJLDYHEB-QIYLELGZSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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