Drug General Information
Drug ID
DX5RBN
Drug Name
(S)-3-Methyl-2-(3-phenyl-thioureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide
Synonyms
CHEMBL1791000
Indication Discovery agent Investigative [1587926]
Formula
C24H28N4O2S
Canonical SMILES
CC[C@@H](C)[C@H](\\N=C(/S)\\Nc1ccccc1)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C=O
InChI
InChI=1S/C24H28N4O2S/c1-3-16(2)22(28-24(31)27-18-9-5-4-6-10-18)23(30)26-19(15-29)13-17-14-25-21-12-8-7-11-20(17)21/h4-12,14-16,19,22,25H,3,13H2,1-2H3,(H,26,30)(H2,27,28,31)/t16-,19-,22+/m1/s1
InChIKey
ZBTGGZNSFPJDHD-PERKRYKHSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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