Drug General Information
Drug ID
DX5XRK
Drug Name
2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indazol-5-yl)acetic acid
Synonyms
CHEMBL210917
Indication Discovery agent Investigative [1587926]
Formula
C23H22F3N3O4
Canonical SMILES
CCCc1c(OCCCn2ncc3cc(CC(=O)O)ccc23)ccc4c(noc14)C(F)(F)F
InChI
InChI=1S/C23H22F3N3O4/c1-2-4-16-19(8-6-17-21(16)33-28-22(17)23(24,25)26)32-10-3-9-29-18-7-5-14(12-20(30)31)11-15(18)13-27-29/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,30,31)
InChIKey
ZFCIXIWMXLHUDY-UHFFFAOYSA-N
Target and Pathway
Target(s) Peroxisomeproliferator activated receptor delta Target Info [1587926]
Oxysterols receptor LXR-alpha Target Info [1587926]
KEGG Pathway PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemiahsa03320:PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway and Pluripotency
Nuclear Receptors in Lipid Metabolism and Toxicity
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Adipogenesis
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
PPAR Alpha Pathway
Liver X Receptor Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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