Drug General Information
Drug ID
DX6BAM
Drug Name
N-(4-{1-Ethyl-4-[2-({[3-(4-methyl-1-piperazinyl)propyl]amino}-methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea
Synonyms
CHEMBL1095989
Indication Discovery agent Investigative [1587926]
Formula
C34H41N9O
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(CNCCCN4CCN(C)CC4)cc23)c(n1)c5ccc(NC(=O)Nc6ccccc6)cc5
InChI
InChI=1S/C34H41N9O/c1-3-43-24-31(32(40-43)25-10-12-27(13-11-25)39-34(44)38-26-8-5-4-6-9-26)29-14-16-36-33-30(29)22-28(37-33)23-35-15-7-17-42-20-18-41(2)19-21-42/h4-6,8-14,16,22,24,35H,3,7,15,17-21,23H2,1-2H3,(H,36,37)(H2,38,39,44)
InChIKey
RDIZFHYTFVBBCX-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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