Drug General Information
Drug ID
DX6J2L
Drug Name
(6,7-Dimethoxy-quinazolin-4-yl)-methyl-phenyl-amine; hydrochloride
Synonyms
RPR-108514A; CHEMBL543669
Indication Discovery agent Investigative [1587926]
Formula
C17H18ClN3O2
Canonical SMILES
Cl.COc1cc2ncnc(N(C)c3ccccc3)c2cc1OC
InChI
InChI=1S/C17H17N3O2.ClH/c1-20(12-7-5-4-6-8-12)17-13-9-15(21-2)16(22-3)10-14(13)18-11-19-17;/h4-11H,1-3H3;1H
InChIKey
LPXMNVUTNCZLBT-UHFFFAOYSA-N
Target and Pathway
Target(s) Epidermal growth factor receptor III Target Info [1587926]
Macrophage colony-stimulating factor 1 Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Hematopoietic cell lineage
TNF signaling pathway
Rheumatoid arthritis
NetPath Pathway TSH Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Integrins in angiogenesis
WikiPathways Cytokines and Inflammatory Response
Hematopoietic Stem Cell Differentiation
Differentiation Pathway
miR-targeted genes in muscle cell - TarBase
Folate Metabolism
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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