Drug General Information
Drug ID
DX6TGM
Drug Name
5-Bromo-2-((1S,4R)-4-hydroxymethyl-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol
Synonyms
CHEMBL296156
Indication Discovery agent Investigative [1587926]
Formula
C18H25BrO3
Canonical SMILES
COc1cc(C[C@@H]2C(=C)C[C@H](CO)CC2(C)C)c(O)cc1Br
InChI
InChI=1S/C18H25BrO3/c1-11-5-12(10-20)9-18(2,3)14(11)6-13-7-17(22-4)15(19)8-16(13)21/h7-8,12,14,20-21H,1,5-6,9-10H2,2-4H3/t12-,14+/m0/s1
InChIKey
HHTOHVPKRLNAMM-GXTWGEPZSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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