Drug General Information
Drug ID
DX7FRM
Drug Name
6-{1-[2-(Quinolin-5-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one
Synonyms
CHEMBL183332
Indication Discovery agent Investigative [1587926]
Formula
C24H25N3O4
Canonical SMILES
O=C1COc2ccc(OC3CCN(CCOc4cccc5ncccc45)CC3)cc2N1
InChI
InChI=1S/C24H25N3O4/c28-24-16-30-23-7-6-18(15-21(23)26-24)31-17-8-11-27(12-9-17)13-14-29-22-5-1-4-20-19(22)3-2-10-25-20/h1-7,10,15,17H,8-9,11-14,16H2,(H,26,28)
InChIKey
JRTSFKNQYRTZER-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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