Drug General Information
Drug ID
DX8BJF
Drug Name
N-(2-Chloro-phenyl)-2-[(3R,5S,7R)-2-oxo-7-phenyl-5-o-tolyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide
Synonyms
CHEMBL320821
Indication Discovery agent Investigative [1587926]
Formula
C35H35ClN4O3
Canonical SMILES
Cc1cccc(NC(=O)N[C@@H]2C[C@@H](C[C@@H](N(CC(=O)Nc3ccccc3Cl)C2=O)c4ccccc4)c5ccccc5C)c1
InChI
InChI=1S/C35H35ClN4O3/c1-23-11-10-15-27(19-23)37-35(43)39-31-20-26(28-16-7-6-12-24(28)2)21-32(25-13-4-3-5-14-25)40(34(31)42)22-33(41)38-30-18-9-8-17-29(30)36/h3-19,26,31-32H,20-22H2,1-2H3,(H,38,41)(H2,37,39,43)/t26-,31+,32+/m0/s1
InChIKey
GQFWYWXTSTVXPK-OODHRNECSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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