Drug General Information
Drug ID
DX9FCH
Drug Name
N-[(3R)-1-cyano-3-pyrrolidinyl]-N'-phenylurea
Synonyms
CHEMBL1672424
Indication Discovery agent Investigative [1587926]
Formula
C12H14N4O
Canonical SMILES
O=C(N[C@@H]1CCN(C1)C#N)Nc2ccccc2
InChI
InChI=1S/C12H14N4O/c13-9-16-7-6-11(8-16)15-12(17)14-10-4-2-1-3-5-10/h1-5,11H,6-8H2,(H2,14,15,17)/t11-/m1/s1
InChIKey
ORYZNHBPJFZGJG-LLVKDONJSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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