Drug General Information
Drug ID
DX9JKG
Drug Name
6-(isobutylthio)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Synonyms
CHEMBL385451
Indication Discovery agent Investigative [1587926]
Formula
C11H17N3O4S3
Canonical SMILES
CC(C)CSc1cc2NCNS(=O)(=O)c2cc1S(=O)(=O)N
InChI
InChI=1S/C11H17N3O4S3/c1-7(2)5-19-9-3-8-10(4-11(9)20(12,15)16)21(17,18)14-6-13-8/h3-4,7,13-14H,5-6H2,1-2H3,(H2,12,15,16)
InChIKey
PSHQSUDFAALNLZ-UHFFFAOYSA-N
Target and Pathway
Target(s) Carbonic anhydrase II Target Info [1587926]
Carbonic anhydrase XII Target Info [1587926]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolism
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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