Drug General Information
Drug ID
DX9MIR
Drug Name
{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-dimethyl-amine
Synonyms
CHEMBL336353
Indication Discovery agent Investigative [1587926]
Formula
C28H27FN2O
Canonical SMILES
CN(C)c1ccccc1\\C=C\\2/Oc3ccc(F)cc3c4ccc5NC(C)(C)C=C(C)c5c24
InChI
InChI=1S/C28H27FN2O/c1-17-16-28(2,3)30-22-12-11-20-21-15-19(29)10-13-24(21)32-25(27(20)26(17)22)14-18-8-6-7-9-23(18)31(4)5/h6-16,30H,1-5H3/b25-14-
InChIKey
CWXNSHLNBNLSSS-QFEZKATASA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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