Drug General Information
Drug ID
DXC6MV
Drug Name
[3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin-5-yloxy)-ethyl]-amine
Synonyms
CHEMBL125902
Indication Discovery agent Investigative [1587926]
Formula
C21H21FN4O
Canonical SMILES
Fc1ccc2[nH]cc(CCCNCCOc3cccc4nccnc34)c2c1
InChI
InChI=1S/C21H21FN4O/c22-16-6-7-18-17(13-16)15(14-26-18)3-2-8-23-11-12-27-20-5-1-4-19-21(20)25-10-9-24-19/h1,4-7,9-10,13-14,23,26H,2-3,8,11-12H2
InChIKey
VWAVMVBNSJOHSA-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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