Drug Information

Drug General Information
Drug ID
DXC96L
Drug Name
(R)-5-(4-Methoxy-benzenesulfonyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydroxyamide
Synonyms
CHEMBL57725
Indication Discovery agent Investigative [1587926]
Formula
C15H18N4O5S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3ncn(C)c3C[C@@H]2C(=O)NO
InChI
InChI=1S/C15H18N4O5S/c1-18-9-16-12-8-19(14(7-13(12)18)15(20)17-21)25(22,23)11-5-3-10(24-2)4-6-11/h3-6,9,14,21H,7-8H2,1-2H3,(H,17,20)/t14-/m1/s1
InChIKey
HRTBORRCNRXWRR-CQSZACIVSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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