Drug Information

Drug General Information
Drug ID
DXD0YI
Drug Name
N1-3-[5-(2-Methyl-6-[(3-morpholinopropyl)amino]-4-pyrimidinylamino)-1H-3-pyrazolyl]phenyl-1-benzenesulfonamide
Synonyms
CHEMBL1807789
Indication Discovery agent Investigative [1587926]
Formula
C27H32N8O3S
Canonical SMILES
Cc1nc(NCCCN2CCOCC2)cc(Nc3cc(n[nH]3)c4cccc(NS(=O)(=O)c5ccccc5)c4)n1
InChI
InChI=1S/C27H32N8O3S/c1-20-29-25(28-11-6-12-35-13-15-38-16-14-35)19-26(30-20)31-27-18-24(32-33-27)21-7-5-8-22(17-21)34-39(36,37)23-9-3-2-4-10-23/h2-5,7-10,17-19,34H,6,11-16H2,1H3,(H3,28,29,30,31,32,33)
InChIKey
FMECAVUOMUCKKM-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
FL cytokine receptor Target Info [1587926]
KEGG Pathway Oocyte meiosishsa04060:Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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