Drug Information

Drug General Information
Drug ID
DXD4LG
Drug Name
5-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-4-methoxy-thiophene-3-carboxylic acid methyl ester
Synonyms
CHEMBL140305
Indication Discovery agent Investigative [1587926]
Formula
C17H18N2O7S2
Canonical SMILES
COC(=O)c1csc(c1OC)S(=O)(=O)N2Cc3ccccc3CC2C(=O)NO
InChI
InChI=1S/C17H18N2O7S2/c1-25-14-12(16(21)26-2)9-27-17(14)28(23,24)19-8-11-6-4-3-5-10(11)7-13(19)15(20)18-22/h3-6,9,13,22H,7-8H2,1-2H3,(H,18,20)
InChIKey
QESMDPOTHYLJHG-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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