Drug General Information
Drug ID
DXF1SB
Drug Name
1-(1-(3,5-dichlorophenyl)-3-phenylpropylidene)thiosemicarbazide
Synonyms
CHEMBL406601
Indication Discovery agent Investigative [1587926]
Formula
C16H15Cl2N3S
Canonical SMILES
NC(=S)N\\N=C(/CCc1ccccc1)\\c2cc(Cl)cc(Cl)c2
InChI
InChI=1S/C16H15Cl2N3S/c17-13-8-12(9-14(18)10-13)15(20-21-16(19)22)7-6-11-4-2-1-3-5-11/h1-5,8-10H,6-7H2,(H3,19,21,22)/b20-15+
InChIKey
SCXZQHUVAMQHQY-HMMYKYKNSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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