Drug Information

Drug General Information
Drug ID
DXFB2X
Drug Name
8-(3-methylisothiazol-5-ylamino)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine-6-carbonitrile
Synonyms
CHEMBL1801128
Indication Discovery agent Investigative [1587926]
Formula
C14H10N8S
Canonical SMILES
Cc1cc(Nc2nc(cn3c(cnc23)c4cn[nH]c4)C#N)sn1
InChI
InChI=1S/C14H10N8S/c1-8-2-12(23-21-8)20-13-14-16-6-11(9-4-17-18-5-9)22(14)7-10(3-15)19-13/h2,4-7H,1H3,(H,17,18)(H,19,20)
InChIKey
UCKMYULEGLLJLE-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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