Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXGA9S
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| Drug Name |
4'-Isoxazol-5-yl-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide
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| Synonyms |
CHEMBL199014
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C25H24N4O3
|
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| Canonical SMILES |
O=C(NC1(CCCCC1)C(=O)NCC#N)c2ccc(cc2)c3ccc(cc3)c4oncc4
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| InChI |
InChI=1S/C25H24N4O3/c26-15-17-27-24(31)25(13-2-1-3-14-25)29-23(30)21-10-6-19(7-11-21)18-4-8-20(9-5-18)22-12-16-28-32-22/h4-12,16H,1-3,13-14,17H2,(H,27,31)(H,29,30)
|
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| InChIKey |
IEMWVIHJZPIGLR-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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