Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXGS2M
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| Drug Name |
4'-[1-(2-Hydroxy-ethyl)-piperidin-4-yloxy]-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide
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| Synonyms |
CHEMBL372410
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H36N4O4
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| Canonical SMILES |
OCCN1CCC(CC1)Oc2ccc(cc2)c3ccc(cc3)C(=O)NC4(CCCCC4)C(=O)NCC#N
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| InChI |
InChI=1S/C29H36N4O4/c30-16-17-31-28(36)29(14-2-1-3-15-29)32-27(35)24-6-4-22(5-7-24)23-8-10-25(11-9-23)37-26-12-18-33(19-13-26)20-21-34/h4-11,26,34H,1-3,12-15,17-21H2,(H,31,36)(H,32,35)
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| InChIKey |
ARUOKGIJLBMXHU-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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