Drug General Information
Drug ID
DXH6GP
Drug Name
4-(3-Adamantan-1-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)-benzoic acid
Synonyms
CHEMBL257577
Indication Discovery agent Investigative [1587926]
Formula
C21H22N6O2
Canonical SMILES
OC(=O)c1ccc(Nc2ncc3nnn(c3n2)C45CC6CC(CC(C6)C4)C5)cc1
InChI
InChI=1S/C21H22N6O2/c28-19(29)15-1-3-16(4-2-15)23-20-22-11-17-18(24-20)27(26-25-17)21-8-12-5-13(9-21)7-14(6-12)10-21/h1-4,11-14H,5-10H2,(H,28,29)(H,22,23,24)
InChIKey
HZOKUCWZAVEKGI-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Glycogen synthase kinase-3 Target Info [1587926]
KEGG Pathway Oocyte meiosis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingbetacatenin_deg_pathway:Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-198323:AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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