Drug Information

Drug General Information
Drug ID
DXHE4A
Drug Name
[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-quinolin-8-yl-methanone
Synonyms
CHEMBL355262
Indication Discovery agent Investigative [1587926]
Formula
C28H24BrClN4O
Canonical SMILES
Clc1ccc2C(N3CCN(CC3)C(=O)c4cccc5cccnc45)c6ncc(Br)cc6CCc2c1
InChI
InChI=1S/C28H24BrClN4O/c29-21-15-20-7-6-19-16-22(30)8-9-23(19)27(26(20)32-17-21)33-11-13-34(14-12-33)28(35)24-5-1-3-18-4-2-10-31-25(18)24/h1-5,8-10,15-17,27H,6-7,11-14H2
InChIKey
GCTRGRVRBMORMC-UHFFFAOYSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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