Drug General Information
Drug ID
DXHM3M
Drug Name
N-2-fluorophenyl-2-3-7-3-4-hydroxymethyl-piperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-acetamide
Synonyms
CHEMBL425280
Indication Discovery agent Investigative [1587926]
Formula
C29H34FN7O4
Canonical SMILES
COc1cc2c(Nc3cc(CC(=O)Nc4ccccc4F)[nH]n3)ncnc2cc1OCCCN5CCC(CO)CC5
InChI
InChI=1S/C29H34FN7O4/c1-40-25-15-21-24(16-26(25)41-12-4-9-37-10-7-19(17-38)8-11-37)31-18-32-29(21)34-27-13-20(35-36-27)14-28(39)33-23-6-3-2-5-22(23)30/h2-3,5-6,13,15-16,18-19,38H,4,7-12,14,17H2,1H3,(H,33,39)(H2,31,32,34,35,36)
InChIKey
ADTSCWGDALDZSK-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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