Drug Information

Drug General Information
Drug ID
DXI5OY
Drug Name
[3-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid ethyl ester
Synonyms
CHEMBL342374
Indication Discovery agent Investigative [1587926]
Formula
C19H21N3O6S
Canonical SMILES
CCOC(=O)Nc1cccc(c1)S(=O)(=O)N2Cc3ccccc3CC2C(=O)NO
InChI
InChI=1S/C19H21N3O6S/c1-2-28-19(24)20-15-8-5-9-16(11-15)29(26,27)22-12-14-7-4-3-6-13(14)10-17(22)18(23)21-25/h3-9,11,17,25H,2,10,12H2,1H3,(H,20,24)(H,21,23)
InChIKey
HPJZLIJTRCEDRH-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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