Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXI7KR
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| Drug Name |
(S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(1-(morpholine-4-carbonyl)cyclopropyl)biphenyl-4-yl)ethylamino)pentanamide
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| Synonyms |
CHEMBL1288526
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C37H40F4N4O3
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| Canonical SMILES |
CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)c2ccc(cc2)C3(CC3)C(=O)N4CCOCC4)C(F)(F)F)C(=O)N[C@@H](Cc5ccccc5)C#N
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| InChI |
InChI=1S/C37H40F4N4O3/c1-35(2,38)23-31(33(46)43-30(24-42)22-25-6-4-3-5-7-25)44-32(37(39,40)41)28-10-8-26(9-11-28)27-12-14-29(15-13-27)36(16-17-36)34(47)45-18-20-48-21-19-45/h3-15,30-32,44H,16-23H2,1-2H3,(H,43,46)/t30-,31-,32-/m0/s1
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| InChIKey |
ZPVHBQIGHVBBKF-CPCREDONSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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