Drug General Information
Drug ID
DXJJ0L
Drug Name
2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic acid cyanomethyl-amide
Synonyms
CHEMBL365007
Indication Discovery agent Investigative [1587926]
Formula
C12H16BrN3OS
Canonical SMILES
CC(C)C[C@H](Nc1cscc1Br)C(=O)NCC#N
InChI
InChI=1S/C12H16BrN3OS/c1-8(2)5-10(12(17)15-4-3-14)16-11-7-18-6-9(11)13/h6-8,10,16H,4-5H2,1-2H3,(H,15,17)/t10-/m0/s1
InChIKey
KGJLXDHUTKATFA-JTQLQIEISA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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