Drug General Information
Drug ID
DXK4LD
Drug Name
9-Cyclopentyl-6-(2-{4-[2-(2-methoxy-ethylamino)-ethoxy]-benzyloxy}-phenylamino)-9H-purine-2-carbonitrile
Synonyms
CHEMBL361499
Indication Discovery agent Investigative [1587926]
Formula
C29H33N7O3
Canonical SMILES
COCCNCCOc1ccc(COc2ccccc2Nc3nc(nc4c3ncn4C5CCCC5)C#N)cc1
InChI
InChI=1S/C29H33N7O3/c1-37-16-14-31-15-17-38-23-12-10-21(11-13-23)19-39-25-9-5-4-8-24(25)33-28-27-29(35-26(18-30)34-28)36(20-32-27)22-6-2-3-7-22/h4-5,8-13,20,22,31H,2-3,6-7,14-17,19H2,1H3,(H,33,34,35)
InChIKey
MLAYQZHQPOWWIL-UHFFFAOYSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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