Drug General Information
Drug ID
DXK9FD
Drug Name
2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-8-methoxy-4-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
Synonyms
CHEMBL382333
Indication Discovery agent Investigative [1587926]
Formula
C26H30FN3O2
Canonical SMILES
CCCN1CC(CN2CCC(=CC2)c3c[nH]c4ccc(F)cc34)Oc5c(OC)cccc15
InChI
InChI=1S/C26H30FN3O2/c1-3-11-30-17-20(32-26-24(30)5-4-6-25(26)31-2)16-29-12-9-18(10-13-29)22-15-28-23-8-7-19(27)14-21(22)23/h4-9,14-15,20,28H,3,10-13,16-17H2,1-2H3
InChIKey
KBGIAHKLLKPEIS-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.