Drug Information

Drug General Information
Drug ID
DXL3I8
Drug Name
N-Hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-2-(2-pyrrolidin-1-yl-acetylamino)-propionamide
Synonyms
CHEMBL90487
Indication Discovery agent Investigative [1587926]
Formula
C22H27N3O6S
Canonical SMILES
CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NC(=O)CN3CCCC3)C(=O)NO
InChI
InChI=1S/C22H27N3O6S/c1-22(21(27)24-28,23-20(26)15-25-13-5-6-14-25)16-32(29,30)19-11-9-18(10-12-19)31-17-7-3-2-4-8-17/h2-4,7-12,28H,5-6,13-16H2,1H3,(H,23,26)(H,24,27)
InChIKey
WGRMVARLTSCXRH-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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