Drug Information

Drug General Information
Drug ID
DXL5JY
Drug Name
2-(5-Dimethylamino-naphthalene-1-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL343818
Indication Discovery agent Investigative [1587926]
Formula
C22H23N3O4S
Canonical SMILES
CN(C)c1cccc2c(cccc12)S(=O)(=O)N3Cc4ccccc4CC3C(=O)NO
InChI
InChI=1S/C22H23N3O4S/c1-24(2)19-11-5-10-18-17(19)9-6-12-21(18)30(28,29)25-14-16-8-4-3-7-15(16)13-20(25)22(26)23-27/h3-12,20,27H,13-14H2,1-2H3,(H,23,26)
InChIKey
RNMKXQYTQJNJRJ-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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