Drug General Information
Drug ID
DXM1VV
Drug Name
3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(5-hydroxy-1H-indole-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid.AcOH
Synonyms
CHEMBL293026
Indication Discovery agent Investigative [1587926]
Formula
C44H52N8O10
Canonical SMILES
CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c3cc4cc(O)ccc4[nH]3)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc5ccccc5)C(=O)N
InChI
InChI=1S/C44H52N8O10/c1-44(2,3)62-43(61)52-35(22-27-24-47-31-14-8-7-13-29(27)31)41(59)49-32(15-9-10-18-46-39(57)34-21-26-20-28(53)16-17-30(26)48-34)40(58)51-36(23-37(54)55)42(60)50-33(38(45)56)19-25-11-5-4-6-12-25/h4-8,11-14,16-17,20-21,24,32-33,35-36,47-48,53H,9-10,15,18-19,22-23H2,1-3H3,(H2,45,56)(H,46,57)(H,49,59)(H,50,60)(H,51,58)(H,52,61)(H,54,55)/t32-,33-,35-,36-/m0/s1
InChIKey
ACWHYMXOCYJYPG-IZVAWUQISA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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