Drug Information

Drug General Information
Drug ID
DXM42I
Drug Name
4-Chloro-N-[1-(4-chloro-benzoyl)-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide
Synonyms
CHEMBL70593
Indication Discovery agent Investigative [1587926]
Formula
C29H18Cl2FN3O3
Canonical SMILES
Fc1ccccc1C2=NC(NC(=O)c3ccc(Cl)cc3)C(=O)N(C(=O)c4ccc(Cl)cc4)c5ccccc25
InChI
InChI=1S/C29H18Cl2FN3O3/c30-19-13-9-17(10-14-19)27(36)34-26-29(38)35(28(37)18-11-15-20(31)16-12-18)24-8-4-2-6-22(24)25(33-26)21-5-1-3-7-23(21)32/h1-16,26H,(H,34,36)
InChIKey
FMPRFCINNRGLNV-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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