Drug Information

Drug General Information
Drug ID
DXN6BO
Drug Name
2-(4-Acetylamino-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL334709
Indication Discovery agent Investigative [1587926]
Formula
C18H19N3O5S
Canonical SMILES
CC(=O)Nc1ccc(cc1)S(=O)(=O)N2Cc3ccccc3CC2C(=O)NO
InChI
InChI=1S/C18H19N3O5S/c1-12(22)19-15-6-8-16(9-7-15)27(25,26)21-11-14-5-3-2-4-13(14)10-17(21)18(23)20-24/h2-9,17,24H,10-11H2,1H3,(H,19,22)(H,20,23)
InChIKey
CAXAOIUOYPZXNV-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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