Drug General Information
Drug ID
DXP7KG
Drug Name
racemic-5-chloro-6-(1H-indol-3-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline
Synonyms
CHEMBL404496
Indication Discovery agent Investigative [1587926]
Formula
C21H23ClN2
Canonical SMILES
CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)c3c[nH]c4ccccc34
InChI
InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
InChIKey
PFUXODWITQFWRK-UHFFFAOYSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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