Drug General Information
Drug ID
DXQ2S2
Drug Name
2-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
Synonyms
CHEMBL471511
Indication Discovery agent Investigative [1587926]
Formula
C20H16F3N5OS2
Canonical SMILES
FC(F)(F)c1cccc(NC(=O)Cc2ncc(CCNc3ncnc4ccsc34)s2)c1
InChI
InChI=1S/C20H16F3N5OS2/c21-20(22,23)12-2-1-3-13(8-12)28-16(29)9-17-25-10-14(31-17)4-6-24-19-18-15(5-7-30-18)26-11-27-19/h1-3,5,7-8,10-11H,4,6,9H2,(H,28,29)(H,24,26,27)
InChIKey
USSPDYYDWFNICI-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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