Drug Information

Drug General Information
Drug ID
DXR5BQ
Drug Name
[(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid benzyl ester
Synonyms
CHEMBL101603
Indication Discovery agent Investigative [1587926]
Formula
C36H34ClN3O4
Canonical SMILES
Oc1ccc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)N3CCC(=C4c5ccc(Cl)cc5CCc6cccnc46)CC3)cc1
InChI
InChI=1S/C36H34ClN3O4/c37-29-12-15-31-28(22-29)11-10-27-7-4-18-38-34(27)33(31)26-16-19-40(20-17-26)35(42)32(21-24-8-13-30(41)14-9-24)39-36(43)44-23-25-5-2-1-3-6-25/h1-9,12-15,18,22,32,41H,10-11,16-17,19-21,23H2,(H,39,43)/t32-/m1/s1
InChIKey
QDZGTJWEJGGEHS-JGCGQSQUSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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