Drug General Information
Drug ID
DXR7QR
Drug Name
N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-7-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide
Synonyms
CHEMBL126002
Indication Discovery agent Investigative [1587926]
Formula
C30H33ClN4O3
Canonical SMILES
Cc1ccc2N(CC(=O)NC(C)(C)C)C(=O)[C@@H](C[C@H](c3ccccc3)c2c1)NC(=O)Nc4cccc(Cl)c4
InChI
InChI=1S/C30H33ClN4O3/c1-19-13-14-26-24(15-19)23(20-9-6-5-7-10-20)17-25(28(37)35(26)18-27(36)34-30(2,3)4)33-29(38)32-22-12-8-11-21(31)16-22/h5-16,23,25H,17-18H2,1-4H3,(H,34,36)(H2,32,33,38)/t23-,25-/m1/s1
InChIKey
OULXGYXKPKVJPL-ILBGXUMGSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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