Drug General Information
Drug ID
DXT6YC
Drug Name
N-[(3R)-1-cyano-3-pyrrolidinyl]-2,5-bis(methyloxy)benzenesulfonamide
Synonyms
CHEMBL1672426
Indication Discovery agent Investigative [1587926]
Formula
C13H17N3O4S
Canonical SMILES
COc1ccc(OC)c(c1)S(=O)(=O)N[C@@H]2CCN(C2)C#N
InChI
InChI=1S/C13H17N3O4S/c1-19-11-3-4-12(20-2)13(7-11)21(17,18)15-10-5-6-16(8-10)9-14/h3-4,7,10,15H,5-6,8H2,1-2H3/t10-/m1/s1
InChIKey
SRQKADSCZJGWOI-SNVBAGLBSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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