Drug Information

Drug General Information
Drug ID
DXU8HX
Drug Name
1-(benzylsulfonyl)-3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide
Synonyms
CHEMBL250709
Indication Discovery agent Investigative [1587926]
Formula
C24H28N2O7S2
Canonical SMILES
CC#CCOc1ccc(cc1)S(=O)(=O)CC2(CCCN(C2)S(=O)(=O)Cc3ccccc3)C(=O)NO
InChI
InChI=1S/C24H28N2O7S2/c1-2-3-16-33-21-10-12-22(13-11-21)34(29,30)19-24(23(27)25-28)14-7-15-26(18-24)35(31,32)17-20-8-5-4-6-9-20/h4-6,8-13,28H,7,14-19H2,1H3,(H,25,27)
InChIKey
ZXFJUXBYVRDBQU-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Matrix metalloproteinase-14 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancerhsa04668:TNF signaling pathway
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventshif2pathway:HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinase
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer
Degradation of collagen
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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