Drug General Information
Drug ID
DXUC9B
Drug Name
(S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-2-(2-(4-chlorophenylamino)-2-methylpropanamido)-4-methylpentanamide
Synonyms
CHEMBL207558
Indication Discovery agent Investigative [1587926]
Formula
C26H33ClN4O3
Canonical SMILES
CC(C)C[C@H](NC(=O)C(C)(C)Nc1ccc(Cl)cc1)C(=O)N[C@@H](COCc2ccccc2)C#N
InChI
InChI=1S/C26H33ClN4O3/c1-18(2)14-23(30-25(33)26(3,4)31-21-12-10-20(27)11-13-21)24(32)29-22(15-28)17-34-16-19-8-6-5-7-9-19/h5-13,18,22-23,31H,14,16-17H2,1-4H3,(H,29,32)(H,30,33)/t22-,23+/m1/s1
InChIKey
FNBOJIGEVFOKBR-PKTZIBPZSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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