Drug Information

Drug General Information
Drug ID
DXV7JP
Drug Name
2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide
Synonyms
CHEMBL1091617
Indication Discovery agent Investigative [1587926]
Formula
C26H25N3O3
Canonical SMILES
COc1ccc(OC)c(CC(=O)Nc2cc3c(\\C=C\\c4ccccc4)n[nH]c3cc2C)c1
InChI
InChI=1S/C26H25N3O3/c1-17-13-24-21(22(28-29-24)11-9-18-7-5-4-6-8-18)16-23(17)27-26(30)15-19-14-20(31-2)10-12-25(19)32-3/h4-14,16H,15H2,1-3H3,(H,27,30)(H,28,29)/b11-9+
InChIKey
KAHHZLXTLVPZAC-PKNBQFBNSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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