Drug General Information
Drug ID
DXW80V
Drug Name
(S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol
Synonyms
CHEMBL60748
Indication Discovery agent Investigative [1587926]
Formula
C25H28N2O2S
Canonical SMILES
Cc1ccc2cc(sc2c1)C3CCN(C[C@H](O)COc4cccc5[nH]ccc45)CC3
InChI
InChI=1S/C25H28N2O2S/c1-17-5-6-19-14-25(30-24(19)13-17)18-8-11-27(12-9-18)15-20(28)16-29-23-4-2-3-22-21(23)7-10-26-22/h2-7,10,13-14,18,20,26,28H,8-9,11-12,15-16H2,1H3/t20-/m0/s1
InChIKey
IKEGNVUTXPMWNG-FQEVSTJZSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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